Article

Comprehensive transcriptomic and proteomic profiling of mTOR-related epilepsy

2026-03-11

Abstract excerpt

Malformations of cortical development (MCDs) are a major cause of drug-resistant epilepsy (DRE) in children. A subset of MCDs, including focal cortical dysplasia type II, tuberous sclerosis complex, and hemimegalencephaly, shares characteristic histopathological features and somatic mutations in genes within the PI3K–AKT–mTOR signaling cascade, and is termed mTORopathies. However, the molecular mechanisms that dri...

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Literature Corpus work: d10a902b-c5d3-5871-9cdc-a11d0ecd1fb8
DOI: 10.64898/2026.03.10.710809

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