Article

Ectopic HCN4 expression drives mTOR-dependent epilepsy

2019-11-24

Abstract excerpt

The causative link between focal cortical malformations (FCM) and epilepsy is well-accepted, especially among patients with focal cortical dysplasia type II (FCDII) and tuberous sclerosis complex (TSC). However, the mechanisms underlying seizures remain unclear. Using a mouse model of TSC- and FCDII-associated FCM, we show that FCM neurons are responsible for seizure activity via their unexpected abnormal expressi...

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Literature Corpus work: ffacd627-57d5-5cfc-908c-206012867b55
DOI: 10.1101/853820

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