Article

TGF-β2 regulates neuronal Ankyrin-G and promotes its interaction with KCC2

2023-12-06

Abstract excerpt

<h4>ABSTRACT</h4> The neuronal K + /Cl - cotransporter 2 (KCC2) is the major Cl - extruder in CNS neurons and responsible for fast hyperpolarizing postsynaptic inhibition in mature neurons. Impaired KCC2 function has been associated with several brain pathologies. KCC2 forms immunocomplexes with several proteins that may regulate KCC2 membrane trafficking, stability and function, thus, tuning important cellula...

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Literature Corpus work: fae3edfd-933a-5bfb-aff3-02b0e0ef7f8c
DOI: 10.1101/2023.12.05.570078

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