Article

Rac1, Rac3 GTPases and TPC2 are required for axonal outgrowth and migration of cortical interneurons

2022-11-07

Abstract excerpt

<h4>ABSTRACT</h4> Rho GTPases, among them Rac1 and Rac3, are major transducers of extracellular signals and are involved in multiple cellular processes. In cortical interneurons, the neurons that control excitation/inhibition balance of cortical circuits, Rac1 and Rac3 are essential for their development. Ablation of both, leads to a severe reduction in the numbers of mature interneurons found in the murine corte...

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Literature Corpus work: f9fc6020-6c34-5c85-a6a9-6017391ce087
DOI: 10.1101/2022.11.07.515393

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