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Article

RAB18 Regulates Extrahepatic SiRNA-Mediated Gene Silencing Efficacy

2024-02-27

Abstract excerpt

<title>Abstract</title> <p>Small interfering RNAs (siRNAs) hold considerable therapeutic potential to selectively silence previously “undruggable” disease-associated targets, offering new opportunities to fight human diseases. This therapeutic strategy, however, is limited by the inability of naked siRNAs to passively diffuse across cellular membranes due to their large molecular size and negative charge. Deliver...

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Identifiers and source

Literature Corpus work
fadf651f-20ea-5342-8491-a143c54a5bc9
DOI
10.21203/rs.3.rs-3954158/v1
Open publication

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RAB18 Regulates Extrahepatic SiRNA-Mediated Gene Silencing EfficacyDOI 10.21203/rs.3.rs-3954158/v1
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