Article

Hepatic retromer is essential for systemic cholesterol homeostasis by regulating lysosomal cholesterol metabolism

2023-08-09

Abstract excerpt

<h4>Background</h4> Disturbed hepatic cholesterol homeostasis is associated with multiple diseases, including atherosclerotic cardiovascular disease and metabolic dysfunction– associated steatotic liver disease. The endo-lysosomal system is essential for cholesterol uptake and intracellular distribution, yet the mechanisms governing these processes remain incompletely understood. Here, we investigated the impact...

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Literature Corpus work: 4aeecf18-2ba9-5e86-a3df-260538bc3c7c
DOI: 10.1101/2023.08.09.552611

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