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Article

High-density lipoproteins for the systemic delivery of short interfering RNA

9 Dec 2013

Abstract excerpt

INTRODUCTION: RNA interference (RNAi) is a powerful mechanism for gene silencing with the potential to greatly impact the development of new therapies for many human diseases. Short interfering RNAs (siRNAs) may be the ideal molecules for therapeutic RNAi. However, therapeutic siRNAs face significant challenges that must be overcome prior to widespread clinical use. Many efforts have been made to overcome the...

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PMID: 24313310
DOI: 10.1517/17425247.2014.866089

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