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Article

Differential Regulation of Lipoprotein and Hepatitis C Virus Secretion by Rab1b.

Cell reports - 10 Oct 2017

Takacs Constantin N, Andreo Ursula, Dao Thi Viet Loan, Wu Xianfang, Gleason Caroline E, Itano Michelle S, Spitz-Becker Gabriella S, Belote Rachel L, Hedin Brenna R, Scull Margaret A, Rice Charles M, Simon Sanford M

Abstract excerpt

Secretory cells produce diverse cargoes, yet how they regulate concomitant secretory traffic remains insufficiently explored. Rab GTPases control intracellular vesicular transport. To map secretion pathways, we generated a library of lentivirus-expressed dominant-negative Rab mutants and used it in a large-scale screen to identify regulators of hepatic lipoprotein secretion. We identified several candidate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29020629
DOI: 10.1016/j.celrep.2017.09.053
PMCID: PMC5685655

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