Article

<i>RAB18</i> is a key regulator of GalNAc conjugated siRNA induced silencing in Hep3B cells

2022-01-09

Abstract excerpt

<h4>ABSTRACT</h4> Small interfering RNAs (siRNA) therapeutics have developed rapidly in recent years, despite the challenges associated with delivery of large, highly charged nucleic acids. Delivery of siRNA therapeutics to the liver has been established, with conjugation of siRNA to N-acetylgalactosamine (GalNAc) providing durable gene knockdown in hepatocytes following subcutaneous injection. GalNAc binds the a...

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Literature Corpus work: e1019e1c-e5bb-5dce-8070-c1971b564125
DOI: 10.1101/2022.01.07.475411

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