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Article

Diverse lipid conjugates for functional extra-hepatic siRNA delivery <i>in vivo</i>

2018-03-26

Abstract excerpt

RNAi-based therapeutics show promising clinical data for treatment of liver-associated disorders. However, siRNA delivery into extra-hepatic tissues remains an obstacle, limiting the use of siRNA-based therapies. Here we report on a first example of chemical engineering of lipophilic conjugates to enable extra-hepatic delivery. We synthesized a panel of fifteen lipophilic siRNA and evaluated the impact of their ch...

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Literature Corpus work
c2c038c0-93e1-5ffa-8fc9-c08778769ccd
DOI
10.1101/289439
Open publication

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Diverse lipid conjugates for functional extra-hepatic siRNA delivery <i>in vivo</i>DOI 10.1101/289439
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