Article

RAB18 confers protection to lipid droplets from lysolipophagy and counters cellular steatosis

2023-03-11

Abstract excerpt

Lipid droplet (LD) enlargement is the most conspicuous cellular phenotype of steatotic liver diseases such as NAFLD and NASH. The small GTPase RAB18 localizes to lipid droplets yet its effects on LD dynamics are unknown. We show that RAB18 localizes to LDs dynamically via the acylation cycle in an activity dependent manner. Removal of RAB18 from LDs through acylation cycle inhibition of RNAi-mediated downregulatio...

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Literature Corpus work: 8c91d802-ebea-5d92-8edd-207c7361a3ff
DOI: 10.1101/2023.03.11.531838

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