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A comprehensive update of siRNA delivery design strategies for targeted and effective gene silencing in gene therapy and other applications

14 Dec 2022

Abstract excerpt

INTRODUCTION: RNA interference (RNAi) using small interfering RNA (siRNA) is a promising strategy to control many genetic disorders by targeting the mRNA of underlying genes and degrade it. However, the delivery of siRNA to targeted organs is highly restricted by several intracellular and extracellular barriers. AREAS COVERED: This review discusses various design strategies developed to overcome siRNA delivery...

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PMID: 36514963
DOI: 10.1080/17460441.2022.2155630

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