Article

MAPKAPK2, a dynamic network biomarker of α-synuclein before its aggregation, was significantly highly expressed in both the brain and peripheral blood of PD patients

2022-08-25

Abstract excerpt

One of the important pathological features of Parkinson's disease (PD) is the pathological aggregation of α-synuclein (α-Syn) in the substantia nigra. Preventing the aggregation of α-Syn has become a potential strategy for treating PD. However, the molecular mechanism of α-Syn aggregation is unclear. In this study, using the dynamic network biomarker (DNB) method, we first identified the critical time point when α...

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Literature Corpus work: ed102226-05d8-5270-ba6e-c7e3efb0d50e
DOI: 10.21203/rs.3.rs-1964495/v1

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