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MAPKAPK2, a potential dynamic network biomarker of α-synuclein prior to its aggregation in PD patients

16 Mar 2023

Abstract excerpt

One of the important pathological features of Parkinson's disease (PD) is the pathological aggregation of α-synuclein (α-Syn) in the substantia nigra. Preventing the aggregation of α-Syn has become a potential strategy for treating PD. However, the molecular mechanism of α-Syn aggregation is unclear. In this study, using the dynamic network biomarker (DNB) method, we first identified the critical time point when...

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PMID: 36927756
DOI: 10.1038/s41531-023-00479-z

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