Article

YAP-controlled MHC-I and CXCL10 expression potentiates antitumor immunity independently of IFNγ signaling

2023-02-25

Abstract excerpt

Many efforts are underway to improve immune checkpoint blockade (ICB) therapy including potentiating MHC-I antigen processing and presentation. Accumulating evidence links the Hippo pathway to immunotherapy response, but the understanding of how the tumor-intrinsic Hippo signaling regulating antitumor immunity is limited. Here, we report that inhibition of the Hippo pathway coactivator YAP in tumor cells increases...

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Literature Corpus work: fad61e1b-6af2-5a6f-bbd8-7358c8a1450a
DOI: 10.1101/2023.02.25.530003

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