Article

Dysregulation of the Hippo pathway enhances PD-L2 transcription to promote cancer immune evasion

2024-05-02

Abstract excerpt

<title>Abstract</title> <p>The Hippo pathway and its downstream effectors, YAP/TAZ, exhibit aberrant regulation across various cancer types, including head and neck squamous cell carcinoma, facilitating cancer cell growth. However, YAP/TAZ influence on cancer immune evasion remains poorly understood. Herein, we show that cancer patients harboring mutations regulating the Hippo pathway and YAP/TAZ hyperactivation...

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Literature Corpus work: 8e291eee-c422-5431-80be-905b00f3034e
DOI: 10.21203/rs.3.rs-4330731/v1

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