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The Crossroads of Cancer Epigenetics and Immune Checkpoint Therapy

30 Nov 2022

Abstract excerpt

Immune checkpoint inhibitors (ICI) have significantly improved treatment outcomes for several types of cancer over the past decade, but significant challenges that limit wider effectiveness of current immunotherapies remain to be addressed. Certain "cold" tumor types, such as pancreatic cancer, exhibit very low response rates to ICI due to intrinsically low immunogenicity. In addition, many patients who initially...

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PMID: 36449280
DOI: 10.1158/1078-0432.ccr-22-0784

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