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Genome-wide gain-of-function screening characterized lncRNA regulators for tumor immune response

7 Dec 2022

Abstract excerpt

The majority of lncRNAs’ roles in tumor immunology remain elusive. This project performed a CRISPR activation screening of 9744 lncRNAs in melanoma cells cocultured with human CD8+T cells. We identified 16 lncRNAs potentially regulating tumor immune response. Further integrative analysis using tumor immunogenomics data revealed thatIL10RB-DTandLINC01198are significantly correlated with tumor immune response and...

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PMID: 36475797
DOI: 10.1126/sciadv.add0005

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