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Article

The Emerging Role of YAP/TAZ in Tumor Immunity

15 Jul 2019

Abstract excerpt

Yes-associated protein (YAP)/WW domain-containing transcription regulator 1 (TAZ) is an important transcriptional regulator and effector of the Hippo signaling pathway that has emerged as a critical determinant of malignancy in many human tumors. YAP/TAZ expression regulates the cross-talk between immune cells and tumor cells in the tumor microenvironment through its influence on T cells, myeloid-derived...

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PMID: 31308148
DOI: 10.1158/1541-7786.mcr-19-0375

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