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Article

YAP1 Inhibition Induces Phenotype Switching of Cancer-Associated Fibroblasts to Tumor Suppressive in Prostate Cancer.

Cancer research - 15 Nov 2024

Song Hongtao, Lu Tong, Han Donghui, Zhang Jiayu, Gan Lunbiao, Xu Chao, Liu Shaojie, Li Peng, Zhang Keying, Hu Zhihao, Li Hongji, Li Yu, Zhao Xiaolong, Zhang Jingliang, Xing Nianzeng, Shi Changhong, Wen Weihong, Yang Fa, Qin Weijun

Abstract excerpt

Prostate cancer rarely responds to immune-checkpoint blockade (ICB) therapies. Cancer-associated fibroblasts (CAF) are critical components of the immunologically "cold" tumor microenvironment and are considered a promising target to enhance the immunotherapy response. In this study, we aimed to reveal the mechanisms regulating CAF plasticity to identify potential strategies to switch CAFs from protumorigenic to...

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Source

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Identifiers

PMID: 39137404
DOI: 10.1158/0008-5472.CAN-24-0932
PMCID: PMC11565174

Genes

YAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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