Article

Yap suppresses T cell function and infiltration in the tumor microenvironment

2019-05-21

Abstract excerpt

<h4>ABSTRACT</h4> A major challenge for cancer immunotherapy is sustaining T cell activation and recruitment in immunosuppressive solid tumors. Here we report that Yap levels are sharply induced upon activation of CD4 + and CD8 + T cells and that Yap functions as an immunosuppressive factor and inhibitor of effector differentiation. Loss of Yap in T cells results in enhanced T cell activation, differentiation a...

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Literature Corpus work: f42dd136-ac3a-5d51-acfd-f60e18bf2f36
DOI: 10.1101/644757

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