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Article

TCF-1 Is Required for CD4 T Cell Persistence Functions during AlloImmunity

21 Feb 2023

Abstract excerpt

The transcription factor T cell factor-1 (TCF-1) is encoded by Tcf7 and plays a significant role in regulating immune responses to cancer and pathogens. TCF-1 plays a central role in CD4 T cell development; however, the biological function of TCF-1 on mature peripheral CD4 T cell-mediated alloimmunity is currently unknown. This report reveals that TCF-1 is critical for mature CD4 T cell stemness and their...

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PMID: 36901757
DOI: 10.3390/ijms24054326

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