Article
<i>TCF-7</i> is dispensable for anti-tumor response but required for persistent function of mature CD8 T cells
2021-03-23
Abstract excerpt
T Cell Factor-1, encoded by TCF-7, is a transcription factor that plays an essential role during T cell development and differentiation. In this manuscript we utilized a pre-clinical model provided evidence that TCF-7 is dispensable for the anti-tumor response, and that TCF-7 suppresses key transcriptional factors Eomes and T-bet and molecules responsible for peripheral CD8 T cell cytolytic function. We discove...
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Identifiers and source
- Literature Corpus work
- d43fd260-0d4a-5ecd-8d3d-d0cc629732c5
- DOI
- 10.1101/2021.03.22.436494