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Article

Role of TCF‐1 in differentiation, exhaustion, and memory of CD8 + T cells: A review

29 Apr 2021

Abstract excerpt

Abstract T cell factor‐1 (TCF‐1) (encoded by the TCF7 gene) is a transcription factor that plays important role during the T cell development and differentiation for T cell to exercise its functions including producing memory T cells. Not only TCF‐1 can modulate the T cell development but also exerts various effects on the differentiation and function of mature CD8 + T cells. In addition, it drives the production...

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PMID: 33913198
DOI: 10.1096/fj.202002566r

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