Article

STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma models

2022-03-01

Abstract excerpt

Immunotherapy has had a tremendous impact on cancer treatment in the past decade, with hitherto unseen responses at advanced and metastatic stages of the disease. However, the aggressive brain tumor glioblastoma (GBM) is highly immunosuppressive and remains largely refractory to current immunotherapeutic approaches. The cGAS-STING cytoplasmic double stranded DNA (dsDNA) sensing pathway has emerged as a next-genera...

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Literature Corpus work: 02ac3418-e2c1-53fe-b5c5-bea1fb0a0e7d
DOI: 10.1101/2022.02.28.481908

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