Article

STING Licensing of Type I Dendritic Cells Potentiates Antitumor Immunity

2024-01-02

Abstract excerpt

Stimulator of interferon genes (STING) is an immune adaptor protein that senses cyclic GMP-AMP (cGAMP) in response to self or microbial cytosolic DNA as a danger signal. STING is ubiquitously expressed in diverse cell populations including cancer cells with distinct cellular functions such as activation of type I interferons, autophagy induction, or triggering apoptosis. It is not well understood whether and which...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ccb147aa-abd0-52a9-96df-b2f14e3fd9a0
DOI: 10.1101/2024.01.02.573934

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

STING Licensing of Type I Dendritic Cells Potentiates Antitumor ImmunityDOI 10.1101/2024.01.02.573934Read

CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumorsSemantic proximity Read

T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapySemantic proximity Read

Discordance in STING-Induced Activation and Cell Death Between Mouse and Human Dendritic Cell PopulationsSemantic proximity Read

Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of CancerSemantic proximity Read

The cGAS-STING Pathway: A Promising Immunotherapy TargetSemantic proximity Read

An NF-κB/IRF1 axis programs cDC1s to drive anti-tumor immunitySemantic proximity Read

Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathwaySemantic proximity Read

A cancer immunotherapy modality based on dendritic cell reprogramming <i>in vivo</i>Semantic proximity Read

PD-1 blockade-driven anti-tumor CD8 <sup>+</sup> T cell immunity requires XCR1 <sup>+</sup> dendritic cellsSemantic proximity Read

Dynamic STING repression orchestrates immune cell development and functionSemantic proximity Read

Single-cell transcriptomics reveal distinct subsets of activated dendritic cells in the tumor microenvironmentSemantic proximity Read

HCMV exploits STING signaling and counteracts IFN and ISG induction to facilitate dendritic cell infectionSemantic proximity Read