Programable Albumin-Hitchhiking Nanobodies Enhance the Delivery of STING Agonists to Potentiate Cancer Immunotherapy

Abstract excerpt

<title>Abstract</title> <p>Stimulator of interferon genes (STING) is a promising target for potentiating antitumor immunity, but multiple pharmacological barriers limit the clinical utility, efficacy, and/or safety of STING agonists. Here we describe a modular platform for systemic administration of STING agonists based on nanobodies engineered for <italic>in situ</italic> hitchhiking of agonist cargo on serum al...

Topics

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• CAR-T cell therapy research
• CRISPR and Genetic Engineering
• Immunotherapy and Immune Responses
• Monoclonal and Polyclonal Antibodies Research
• Nanoplatforms for cancer theranostics
• Nanowire Synthesis and Applications

Identifiers and source

Literature Corpus work

97b83af0-cf5a-5b12-bb3f-cb20ae3b9223

DOI

10.21203/rs.3.rs-3243545/v1