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Targeted Delivery of STING agonist via Albumin Nanoreactor Boosts Immunotherapeutic Efficacy against Aggressive Cancers

2024-07-30

Abstract excerpt

Activating the cytosolic innate immune sensor cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway via natural and synthetic agonists holds great potential for priming robust antitumor immunity. However, the effectiveness of STING agonists is often impeded by the insufficient tumor accumulation, poor cellular entry, and rapid clearance, thus leading to difficulty of their clinic translation....

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Literature Corpus work
d2266729-2ba6-5471-ae88-3233d14b97a2
DOI
10.20944/preprints202407.2354.v1
Open publication

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Targeted Delivery of STING agonist via Albumin Nanoreactor Boosts Immunotherapeutic Efficacy against Aggressive CancersDOI 10.20944/preprints202407.2354.v1
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