Article

Alterations in chromatin accessibility and conformation elucidate genetic mechanisms in ASD

2025-04-04

Abstract excerpt

Genetic risk for psychiatric disorders lies largely within non-coding regions, where the lack of detailed knowledge of gene regulation and chromatin structure has hampered understanding of disease mechanisms. We analyzed chromatin accessibility and 3D genome architecture in brains from 53 ASD and neurotypical individuals, including patients with (dup) 15q11-13. We observed reduced CTCF binding, which had dual effe...

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Literature Corpus work: fabd6373-ad60-5a58-82ff-1c4c5a75d5ba
DOI: 10.1101/2025.04.02.25325129

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