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Article

Evaluation of chromatin accessibility in prefrontal cortex of individuals with schizophrenia.

Nature communications - 7 Aug 2018

Bryois Julien, Garrett Melanie E, Song Lingyun, Safi Alexias, Giusti-Rodriguez Paola, Johnson Graham D, Shieh Annie W, Buil Alfonso, Fullard John F, Roussos Panos, Sklar Pamela, Akbarian Schahram, Haroutunian Vahram, Stockmeier Craig A, Wray Gregory A, White Kevin P, Liu Chunyu, Reddy Timothy E, Ashley-Koch Allison, Sullivan Patrick F, Crawford Gregory E

Abstract excerpt

Schizophrenia genome-wide association studies have identified >150 regions of the genome associated with disease risk, yet there is little evidence that coding mutations contribute to this disorder. To explore the mechanism of non-coding regulatory elements in schizophrenia, we performed ATAC-seq on adult prefrontal cortex brain samples from 135 individuals with schizophrenia and 137 controls, and identified...

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Identifiers

PMID: 30087329
DOI: 10.1038/s41467-018-05379-y
PMCID: PMC6081462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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