Article

Hippocampal circuit-specific enhancement of GABA-inhibition caused by discrete gene regions in a Down syndrome model

2025-07-24

Abstract excerpt

Although Down syndrome (DS), trisomy 21, affects ∼6 million people worldwide, the neural circuit mechanisms underlying the neurophenotypes of impaired learning, memory and language are unknown. A prominent candidate mechanism involves dysfunctional GABA-signalling and GABA A receptor ligands have been proposed as therapeutics to reverse the neurophenotypic effects of DS. By investigating GABA neurotransmission i...

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Literature Corpus work: 749679aa-b783-5faa-bc0d-9016f4fe27b8
DOI: 10.1101/2025.07.21.665861

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