Article

Hyper-recombination in ribosomal DNA is driven by resection-independent RAD51 loading

2023-12-04

Abstract excerpt

Ribosomal DNA (rDNA) encodes the ribosomal RNA genes and represents a genomic region that is intrinsically unstable. Despite decades-long awareness of rDNA instability, the underlying mechanisms and implications for genome integrity remain elusive. Here, we use Bloom Syndrome (BS), a rare genetic disease characterized by DNA repair defects and hyper-unstable rDNA, to investigate the mechanisms leading to rDNA inst...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fa72fb9a-21ca-5228-a717-4cfc3ff2de68
DOI: 10.21203/rs.3.rs-3691410/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hyper-recombination in ribosomal DNA is driven by resection-independent RAD51 loadingDOI 10.21203/rs.3.rs-3691410/v1Read

Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repairSemantic proximity Read

BLM-dependent Break-Induced Replication handles DSBs in transcribed chromatin upon impaired RNA:DNA hybrids dissolutionSemantic proximity Read

RNA Polymerase II-mediated transcription is required for repair of ribosomal DNA breaks in nucleolar caps, guarding against genomic instabilitySemantic proximity Read

Telomere and ribosomal DNA repeats are chromosomal targets of the bloom syndrome DNA helicase.Semantic proximity Read

Recent advances in the nucleolar responses to DNA double-strand breaksSemantic proximity Read

Bloom syndrome and the underlying causes of genetic instability.Semantic proximity Read

Protein UFMylation regulates early events of ribosomal DNA double-stranded break responseSemantic proximity Read

The Nucleolus: In Genome Maintenance and Repair.Semantic proximity Read

JMJD6 participates in the maintenance of ribosomal DNA integrity in response to DNA damageSemantic proximity Read

The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.Semantic proximity Read

Nucleolar responses to DNA double-strand breaksSemantic proximity Read

RIG-I-like receptors sense replication stress through ribosomal DNA integrity to drive inflammationSemantic proximity Read