Article

RIG-I-like receptors sense replication stress through ribosomal DNA integrity to drive inflammation

2026-05-29

Abstract excerpt

Replication stress, a major source of DNA damage and vulnerability in cancer, activates innate immunity through both the cGAS–STING and RIG-I–like receptor (RLR) pathways, yet the mechanism for RLR activation remains poorly understood despite frequent suppression of cGAS–STING in cancer. Here, we show that replication stress induces genomic instability at ribosomal DNA (rDNA), accompanied by aberrant RNA polymeras...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: acac2265-2e41-53a4-a72f-1db54c059785
DOI: 10.64898/2026.05.27.728122

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RIG-I-like receptors sense replication stress through ribosomal DNA integrity to drive inflammationDOI 10.64898/2026.05.27.728122Read

RNA Polymerase II-mediated transcription is required for repair of ribosomal DNA breaks in nucleolar caps, guarding against genomic instabilitySemantic proximity Read

Nucleolar stress generates ribosomal DNA–derived RNA–DNA hybrids that prime innate immunitySemantic proximity Read

Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repairSemantic proximity Read

cGAS and STING: At the intersection of DNA and RNA virus-sensing networksSemantic proximity Read

DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunitySemantic proximity Read

A Variety of Nucleic Acid Species Are Sensed by cGAS, Implications for Its Diverse FunctionsSemantic proximity Read

The multifaceted functions of cGASSemantic proximity Read

The cGAS-STING pathway: a dual regulator of immune response in cancer and therapeutic implicationsSemantic proximity Read

Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseasesSemantic proximity Read

Significance of the cGAS-STING Pathway in Health and DiseaseSemantic proximity Read

Crosstalk between RNA viruses and DNA sensors: Role of the cGAS‐STING signalling pathwaySemantic proximity Read

Human Cancer Cells Sense Cytosolic Nucleic Acids Through the RIG-I–MAVS Pathway and cGAS–STING PathwaySemantic proximity Read