Article
Telomere and ribosomal DNA repeats are chromosomal targets of the bloom syndrome DNA helicase.
BMC cell biology - 27 Oct 2003
Schawalder James, Paric Enesa, Neff Norma F
Abstract excerpt
BACKGROUND: Bloom syndrome is one of the most cancer-predisposing disorders and is characterized by genomic instability and a high frequency of sister chromatid exchange. The disorder is caused by loss of function of a 3' to 5' RecQ DNA helicase, BLM. The exact role of BLM in maintaining genomic...
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