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Article

The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.

Nature communications - 26 Jan 2021

Shorrocks Ann-Marie K, Jones Samuel E, Tsukada Kaima, Morrow Carl A, Belblidia Zoulikha, Shen Johanna, Vendrell Iolanda, Fischer Roman, Kessler Benedikt M, Blackford Andrew N

Abstract excerpt

The Bloom syndrome helicase BLM interacts with topoisomerase IIIα (TOP3A), RMI1 and RMI2 to form the BTR complex, which dissolves double Holliday junctions to produce non-crossover homologous recombination (HR) products. BLM also promotes DNA-end resection, restart of stalled replication forks, and processing of ultra-fine DNA bridges in mitosis. How these activities of the BTR complex are regulated in cells is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33500419
DOI: 10.1038/s41467-020-20818-5
PMCID: PMC7838300

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.PMID 33500419Read ↗

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