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Comparative proteomic analysis highlights metabolic dysfunction in α-synucleinopathy

11 Dec 2020

Abstract excerpt

The synaptic protein α-synuclein is linked through genetics and neuropathology to the pathogenesis of Parkinson's disease and related disorders. However, the mechanisms by which α-synuclein influences disease onset and progression are incompletely understood. To identify pathogenic pathways and therapeutic targets we performed proteomic analysis in a highly penetrant new Drosophila model of α-synucleinopathy. We...

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PMID: 33311497
DOI: 10.1038/s41531-020-00143-w

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