Article

Dopamine Abundance Uncouples Neurodegeneration and Lifespan in a <i>C. elegans</i> Model of Parkinson’s Disease

2026-07-09

Abstract excerpt

The neuropathology of Parkinson’s disease is characterized by α-synuclein (α-syn) aggregation and dopaminergic (DAergic) neurodegeneration. While neuronal loss in C. elegans α-syn-induced neurodegeneration models is temporally age-dependent, prior research indicates it is uncoupled from the organismal aging process. Here we examined transgenic C. elegans expressing human A53T α-syn in DAergic neurons to determin...

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Literature Corpus work: 2975eeb2-eb78-57b5-9384-2b3c840f834a
DOI: 10.64898/2026.07.04.736516

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