Article

Distinct patterns of gene expression changes in the colon and striatum of young mice overexpressing alpha-synuclein support Parkinson Disease as a multi-system process

2023-07-07

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> : Evidence supports a role for the gut-brain axis in Parkinson Disease (PD). Mice overexpressing human wild type α–synuclein (Thy1-haSyn) exhibit slow colonic transit prior to motor deficits, mirroring prodromal constipation in PD. Identifying molecular changes in the gut could provide both biomarkers for early diagnosis and gut-targeted therapies to prevent p...

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Literature Corpus work: dc4f5d28-c9ff-5bef-ba8e-5f8148cc3620
DOI: 10.21203/rs.3.rs-1660160/v2

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