Intestine-derived α-synuclein initiates and aggravates pathogenesis of Parkinson’s disease in Drosophila

Abstract excerpt

<title>Abstract</title> <p>Background Synucleinopathies, the aberrant aggregation of α-Synuclein (α-Syn), are key pathological features of Parkinson’s disease (PD), but the precise role of intestinal α-Syn in the progression of PD remains largely elusive. In a number of genetic PD <italic>Drosophila</italic> models, α-Syn is frequently ectopically expressed in the neural system to investigate the pathobiology of...

Topics

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• alpha-Synuclein
• Animals, Genetically Modified
• Disease Models, Animal
• Drosophila melanogaster
• Genetics, Aging, and Longevity in Model Organisms
• Mutation
• Parkinson Disease
• Parkinson's Disease Mechanisms and Treatments

Identifiers and source

Literature Corpus work

e19de3f8-4736-59f4-853e-ee880cd4e3df

DOI

10.21203/rs.3.rs-1706792/v1