Article

Aging-associated decline in neuronal PD-L1 expression augments CD8+ T cell-mediated neuroinflammation

2025-09-26

Abstract excerpt

<title>Abstract</title> <p>The healthy young brain is free of lymphocyte infiltration, yet this protection declines with aging. Accumulation of peripheral lymphocytes in the aged brain is linked to increased neuroinflammation and neurodegeneration. Whether brain-specific factors limit lymphocyte infiltration, proliferation and activation in the brain, thereby protecting it from inflammatory damage, remains unknow...

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Literature Corpus work: fa1024eb-ec0c-5ebd-872c-2422ea08320e
DOI: 10.21203/rs.3.rs-7322790/v1

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