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Article

Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site

1 Dec 2019

Abstract excerpt

Abstract Background Neuroinflammation, typified by elevated levels of interleukin-1 (IL-1) α and β, and deficits in proteostasis, characterized by accumulation of polyubiquitinated proteins and other aggregates, are associated with neurodegenerative disease independently and through interactions of the two phenomena. We investigated the influence of IL-1β on ubiquitination via its impact on activation of the E3...

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Share to Autophagy in Disease and Therapy
Share to Hippo pathway signaling and YAP/TAZ
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PMID: 31882005
DOI: 10.1186/s12974-019-1669-z

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