Article

Antigen-specific age-related memory CD8 T cells induce and track Alzheimer’s-like neurodegeneration

2024-01-22

Abstract excerpt

Cerebral (Aβ) plaque and (pTau) tangle deposition are hallmarks of Alzheimer’s disease (AD), yet are insufficient to confer complete AD-like neurodegeneration experimentally. Factors acting upstream of Aβ/pTau in AD remain unknown, but their identification could enable earlier diagnosis and more effective treatments. T cell abnormalities are emerging AD hallmarks, and CD8 T cells were recently found to mediate neu...

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Literature Corpus work: 5d4303b9-851d-5c9a-bde9-747b304f6f1a
DOI: 10.1101/2024.01.22.576704

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