Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD8+ T-cells infiltrate Alzheimer’s disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice

29 May 2020

Abstract excerpt

Neuroinflammation is a major contributor to disease progression in Alzheimer’s disease (AD) and is characterized by the activity of brain resident glial cells, in particular microglia cells. However, there is increasing evidence that peripheral immune cells infiltrate the brain at certain stages of AD progression and shape disease pathology. We recently identified CD8+ T-cells in the brain parenchyma of APP-PS1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Nuclear Receptors and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32479993
DOI: 10.1016/j.bbi.2020.05.070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD8+ T-cells infiltrate Alzheimer’s disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic micePMID 32479993Read ↗

Transcriptomic Profiling Identifies CD8+ T Cells in the Brain of Aged and Alzheimer’s Disease Transgenic Mice as Tissue-Resident Memory T CellsSemantic proximity Read ↗

Human Alzheimer's disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology.Semantic proximity Read ↗

Antigen-specific age-related memory CD8 T cells induce and track Alzheimer’s-like neurodegenerationSemantic proximity Read ↗

Microglia in Alzheimer’s DiseaseSemantic proximity Read ↗

Single-cell multiomic analysis reveals the involvement of Type I interferon-responsive CD8+ T cells in amyloid beta-associated memory lossSemantic proximity Read ↗

The Functions and Phenotypes of Microglia in Alzheimer's Disease.Semantic proximity Read ↗

Gene Expression Profiling in the APP/PS1KI Mouse Model of Familial Alzheimer’s DiseaseSemantic proximity Read ↗

T-cell brain infiltration and immature antigen-presenting cells in transgenic models of Alzheimer's disease-like cerebral amyloidosis.Semantic proximity Read ↗

Epigenetic and Transcriptomic Alterations Precede Amyloidosis in the Hippocampus of the Alzheimer’s Disease <i> App <sup>NL-G-F</sup> </i> Knock in Mouse ModelSemantic proximity Read ↗

Microglia in Alzheimer’s disease: pathogenesis, mechanisms, and therapeutic potentialsSemantic proximity Read ↗

Spatial and temporal transcriptomics reveal microglia-astroglia crosstalk in the amyloid-β plaque cell niche of Alzheimer’s diseaseSemantic proximity Read ↗

Uncovering Plaque-Glia Niches in Human Alzheimer’s Disease Brains Using Spatial TranscriptomicsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.