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Article

Developmental social communication deficits in the Shank3 rat model of phelan-mcdermid syndrome and autism spectrum disorder.

Autism research : official journal of the International Society for Autism Research - 1 Apr 2018

Berg Elizabeth L, Copping Nycole A, Rivera Josef K, Pride Michael C, Careaga Milo, Bauman Melissa D, Berman Robert F, Lein Pamela J, Harony-Nicolas Hala, Buxbaum Joseph D, Ellegood Jacob, Lerch Jason P, Wöhr Markus, Silverman Jill L

Abstract excerpt

Mutations in the SHANK3 gene have been discovered in autism spectrum disorder (ASD), and the intellectual disability, Phelan-McDermid Syndrome. This study leveraged a new rat model of Shank3 deficiency to assess complex behavioral phenomena, unique to rats, which display a richer social behavior repertoire than mice. Uniquely detectable emissions of ultrasonic vocalizations (USV) in rats serve as...

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Identifiers

PMID: 29377611
DOI: 10.1002/aur.1925
PMCID: PMC5903935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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