Article
Genetic disruption of cortical interneuron development causes region- and GABA cell type-specific deficits, epilepsy, and behavioral dysfunction.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jan 2003
Powell Elizabeth M, Campbell Daniel B, Stanwood Gregg D, Davis Caleb, Noebels Jeffrey L, Levitt Pat
Abstract excerpt
The generation of properly functioning circuits during brain development requires precise timing of cell migration and differentiation. Disruptions in the developmental plan may lead to neurological and psychiatric disorders. Neocortical circuits rely on inhibitory GABAergic interneurons, the majority of which migrate from subcortical sources. We have shown that the pleiotropic molecule hepatocyte growth...
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