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Article

Autonomous and non-autonomous roles for ephrin-B in interneuron migration.

Developmental biology - 15 Nov 2017

Talebian Asghar, Britton Rachel, Ammanuel Simon, Bepari Asim, Sprouse Francis, Birnbaum Shari G, Szabó Gábor, Tamamaki Nobuaki, Gibson Jay, Henkemeyer Mark

Abstract excerpt

While several studies indicate the importance of ephrin-B/EphB bidirectional signaling in excitatory neurons, potential roles for these molecules in inhibitory neurons are largely unknown. We identify here an autonomous receptor-like role for ephrin-B reverse signaling in the tangential migration of interneurons into the neocortex using ephrin-B (EfnB1/B2/B3) conditional triple mutant (TMlz) mice and a forebrain...

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Identifiers

PMID: 28947178
DOI: 10.1016/j.ydbio.2017.09.024
PMCID: PMC5658245

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