Article
The RacGAP β-Chimaerin is essential for cerebellar granule cell migration.
Scientific reports - 12 Jan 2018
Estep Jason A, Wong Wenny, Wong Yiu-Cheung E, Loui Brian M, Riccomagno Martin M
Abstract excerpt
During mammalian cerebellar development, postnatal granule cell progenitors proliferate in the outer part of the External Granule Layer (EGL). Postmitotic granule progenitors migrate tangentially in the inner EGL before switching to migrate radially inward, past the Purkinje cell layer, to achieve their final position in the mature Granule Cell Layer (GCL). Here, we show that the RacGAP β-chimaerin is expressed...
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