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Interneuron migration defects during corticogenesis contribute to <i>Dyrk1a</i> haploinsufficiency syndrome pathogenesis via actomyosin dynamics deregulations

2023-11-10

Abstract excerpt

<h4>ABSTRACT</h4> Interneuron development is a crucial step of brain corticogenesis. When affected it often leads to brain dysfunctions, such as epilepsy, intellectual disabilities and autism spectrum disorder. Such defects are observed in the DYRK1A -haploinsufficiency syndrome, caused by mutations of DYRK1A , and commonly associated to cortical excitatory/inhibitory imbalance. However, how this imbalance is e...

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Literature Corpus work
07c57a96-e0ed-5186-8cdc-8260f788ef4c
DOI
10.1101/2023.11.09.566424
Open publication

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Interneuron migration defects during corticogenesis contribute to <i>Dyrk1a</i> haploinsufficiency syndrome pathogenesis via actomyosin dynamics deregulationsDOI 10.1101/2023.11.09.566424
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