Article

ARHGEF6-dependent cytoskeletal regulation underlies a conserved program of forebrain interneuron development

2026-03-10

Abstract excerpt

The molecular programs coordinating inhibitory interneuron migration, maturation, and survival during forebrain development remain incompletely understood. Here we investigate ARHGEF6, a RAC1/CDC42 guanine nucleotide exchange factor linked to X-linked intellectual disability (XLID46) and previously studied only at postsynaptic compartments, and reveal an earlier, conserved role in forebrain interneuron development...

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Literature Corpus work: 3426da1f-742d-5e64-b19a-4b6af5d0d0e9
DOI: 10.64898/2026.03.09.710568

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