Rac1 regulates neuronal polarization through the WAVE complex.

doi:10.1523/JNEUROSCI.5395-09.2010

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Article

Rac1 regulates neuronal polarization through the WAVE complex.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 May 2010

Tahirovic Sabina, Hellal Farida, Neukirchen Dorothee, Hindges Robert, Garvalov Boyan K, Flynn Kevin C, Stradal Theresia E, Chrostek-Grashoff Anna, Brakebusch Cord, Bradke Frank

Abstract excerpt

Neuronal migration and axon growth, key events during neuronal development, require distinct changes in the cytoskeleton. Although many molecular regulators of polarity have been identified and characterized, relatively little is known about their physiological role in this process. To study the physiological function of Rac1 in neuronal development, we have generated a conditional knock-out mouse, in which Rac1...

Topics

Angiopoietin-Like Protein 2
Angiopoietin-like Proteins
Angiopoietins
Animals
Animals, Newborn
Apoptosis
Axons
Bromodeoxyuridine
Cell Movement
Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cells, Cultured

Cerebellum

Cofilin 1

Enzyme Inhibitors

Enzyme-Linked Immunosorbent Assay

Growth Cones

Ki-67 Antigen

Luminescent Proteins

Source

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Identifiers

PMID: 20484635
DOI: 10.1523/JNEUROSCI.5395-09.2010
PMCID: PMC6632643

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Rac1 regulates neuronal polarization through the WAVE complex.PMID 20484635Read ↗

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